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KMID : 0355820210420010107
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Korean Journal of Oral Anatomy
2021 Volume.42 No. 1 p.107 ~ p.113
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Effects of lactoferrin admistration on tooth eruption and bone remodeling in newborn rats
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You Yong-Ouk
Kim Min-Jeong
Kim Hyun-Jin
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Abstract
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Tooth eruption is composed of tooth movement through a sequential process that includes tooth development and bone remodeling. The relation between the tooth germ and alveolar bone occurs during bone remodeling of the final position in the dental arch. Lactoferrin (LF) is an iron-binding glycoprotein and one of the regulatory functions of LF has been suggested to have a modulator role in bone remodeling. Since tooth eruption and bone remodeling are closely linked, this study aimed to evaluate the effects of LF administration on tooth eruption and bone remodeling during tooth development in newborn rats. Sprague-Dawley rats were divided into four groups as; vehicle control and LF group (12 ㎍/g/day) with six-day and ten-day administration. Newborn rats in LF group were given daily dose of 12 ㎍/g during postnatal six days and ten days, whereas the vehicle control group was injected with sterile saline. Tooth eruption levels of incisor teeth were assessed macroscopically. Histological examination was carried out under light microscope to inspect alveolar bone containing the molar tooth germs. Tartrate-resistant acid phosphatase (TRAP) staining was also performed to evaluate the osteoclastogenic appearance. The LF group observed the acceleration of tooth eruption in incisor teeth at day ten. Through the histological analysis, the bone matrix in the occlusal portion of the second molar tooth germ in LF-treated rats (12 ㎍/g/day) with ten-day administration was resorbed and, at day six, an increase of the number of osteoclasts in the alveolar process of the bony crypt was exhibited when compared with control groups. These findings appear to indicate a novel role of LF as a modulator during bone remodeling during tooth eruption dissimilar to a physiological regulator of bone growth previously reported in experimental models.
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KEYWORD
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tooth eruption, bone remodeling, lactoferrin, osteoblast, osteoclast
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